By George Gamow
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“If all questions have been replied, all riddles solved, each fold spread out, each wrinkle within the cloth of the Universe smoothed—the maximum and noblest video game within the Universe will be ended, and there will be not anything left for the brain to do yet console itself with minutiae. insufferable! may possibly X continually BE WITH US TO find the money for US excitement!
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Moreover there is no necessary relation between the amount of drug taken up by the cell and the amount of action produced upon the cell. 1 COOK, R. : J. of Physiol. 62, 160 (1926). Types of Action of Drugs on Cells. Discussion. Types of Action of Drugs on Cells. The hypothesis outlined suggests two very distinct types of drug action. (a) Specific action on receptors of cell surface. (b) Action on cell structure. In the first case drugs may be expected to act rapidly by occupying the cell receptors.
100,000 Invertase on sucrose at 10° C and optimum 'PH' • • • • • • • • • Same preparation at 37° C . . Pepsin on protein, carboxyl groups liberated . . . . . . 200 7,000 0,1 to 16 Choline-esterase on butyryl choline at 30° C . . . . . . E and HELLSTROM (1930)' KUHN, HAND and FLORXIN (1931)3; LANGENBECK (1933)' KUHN and BRAUN (1926)6 MOELWYN-HuGHES (1933)8 NORTHROP (1932)7 LANGENBECK (1933)' EASSON and STEDMAN (1936)8 These calculations show that the rates of action vary over a very wide range in the case of different enzymes, but that in several cases more than 1000 substrate molecules are split per second by each enzyme molecule.
Hg. that the amount of carboxyhaemoglobin formed was twice as great in the presence of 4 per cent. oxygen as when no oxygen was present. This paradox can be explained by application of the formulae given above: it depends on the fact that the dissociation curves of HbOs and HbeO follow different courses. This peculiar effect is mentioned here because it is the simplest example known to the writer of a reaction following the" ARNDT-SCHULZ law". In this case a high concentration of oxygen prevents the formation of HbeO but if haemoglobin is exposed to a low concentration of carbon monoxide, then a low concentration of oxygen may increase the formation of HbeO.