Adenoviruses: Model and Vectors in Virus-Host Interactions: by M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler,

By M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler, Petra Böhm (eds.)

After 3 volumes on adenoviruses in 1995 the prior years have noticeable fast growth within the box of adenovirus examine. additionally, adenoviruses have attracted huge curiosity as vectors in gene move regimens.

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Extra resources for Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure, Viral Replication and Host-Cell Interactions

Sample text

On the other hand, this very weak homology was demonstrated with the THEV sequence, which, according to our theory, is an amphibian adenovirus, and thus represents the most ancient type of adenovirus studied to date. We would expect to see an even more obvious similarity with a fish adenovirus. 1986; MIYAZAKI et al. 1998). By electron microscopic examination, the virions of the putative white sturgeon adenovirus also appear to have double-layered shell, although the nature of the inner shell is completely unknown.

Dan in cloning and sequencing of ruminant adenoviruses, as well as in preparation of the line drawings is highly appreciated. We also wish to thank S. L. Farkas and P. Elo for their work on the snake and fish adenoviruses. Special thanks are due to W. Ahne, S. LaPatra and D. Thomson for generously approving the presentation of unpublished sequence results from our collaborative work on the corn snake, white sturgeon and brushtail possum adenovirus isolates, respectively. Note added at the proof stage: The ICTV approved the two new genera in Paris, June 2002, thus Atadenovirus and Siadenovirus are now official taxons.

This assumption is based on the observation that during co-expression of fiber and base proteins in the baculovirus system, no free fiber could be observed - all newly synthesized fiber was immediately taken up in the complex with the penton base (FENDER et al. 1997). Moreover,Ad pentons are easily isolated from the cytoplasmic extracts of infected cells. At the late phase of infectious cycle Ad proteins travel to the nucleus, where virion assembly takes place. Subsequently, a mature virus is released from the host cells.

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