By C. Meyers
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Extra info for AIDS-Associated Viral Carcinogenesis
No definitive conclusions regarding efficacy can be made due to the small and varied group of patients. 79 All studies except the French series by Diez-Martin108 and colleagues have required HIV disease to be under control for HCT, either by low to undetectable HIV viral loads or CD4 counts >100/mm3. AIDS-RELATED HODGKIN’S LYMPHOMA Lymphomas are categorized in two divisions: NHL and HL. 110 The World Health Organization (WHO) classifies HL into two distinct entities: the more commonly diagnosed classical HL and the rare nodular lymphocyte-predominant HL.
The study consisted of 39 patients and antiretrovirals were not given until after the final cycle of chemotherapy. 99 Rituximab Kaplan and colleagues100 reported a randomized trial in the HAART era using CHOP versus CHOP and rituximab (anti-CD20 antibody) given with each cycle and with an additional three monthly doses after complete response was attained. Median event-free survival, approximately a year, was similar between both groups. 027). Up to 60% of deaths were in patients with a CD4 count of <50/mm3, and 40% occurred during the maintenance phase of rituximab.
28 CLINICAL PRESENTATION OF PCNSL Clinical presentation of CNS lymphoma may be characterized by headaches, confusion, lethargy, memory loss, hemiparesis, aphasia, and seizures. 14,29 The lesions are usually large, few in number, and contrast enhanced on neuroimaging. Without treatment most patients with PCNSL are likely to die within three months, even in the absence of AIDS. 31 Methotrexate administered intravenously is able to penetrate the blood–brain barrier and achieve levels high enough to be cytotoxic.