Antiviral Drug Discovery for Emerging Diseases and by Paul F. Torrence

By Paul F. Torrence

Antiviral Drug Discovery provides readers a state of the art view of ways chemical strategies are being mobilized to enhance novel methods that may successfully confront rising ailments and biowarfare. one of several issues mentioned are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. each one bankruptcy discusses hypothetical innovations for the invention of appropriate antiviral brokers, fresh findings regarding biochemistry or drug discovery, and advances within the additional improvement of tested leads within the region. well timed and informative, this e-book essentially delineates the efforts being made to improve new and potent broad-spectrum antiviral brokers.

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Geisbert, T. ; Hensley, L. ; Jahrling, P. ; Geisbert, J. ; Young, H. ; Fredeking, T. ; Rote, W. ; Vlasuk, G. P. Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys. Lancet 2003, 362, 1953–1958. CHAPTER 3 Overview of Antiviral Drug Discovery and Development Christopher K. 1 INTRODUCTION The continuous global emergence of new and reemerging/resurging infectious diseases during the last few decades is the cause of serious public health problems.

This new perspective has led to the development of revised classification schemes that recognize a broad range of microbial threats. 1) include both ‘‘traditional’’ military bioweapons and a variety of emerging pathogens and stratifies them as Category A, B, or C agents. gov/biodefense/. severe disease and death of infected individuals, and by inducing fear, anxiety, and possibly panic in the general population. 1,8 The group also includes other poxviruses, 20 VIRAL BIOTERRORISM AND ANTIVIRAL COUNTERMEASURES such as monkeypox, which causes a milder, less contagious disease than smallpox, but still represents a significant threat, because its occurrence as a zoonosis in Africa makes the virus accessible to terrorists.

Gov/ biodefense/). Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats. Edited by Paul F. Torrence Copyright # 2005 John Wiley & Sons, Inc. 1 Ribavirin In an event of an outbreak of a new emerging viral infection, ribavirin 1 has almost always been the first drug tried. S. 2 NIAID Biodefense Viral Pathogens Categories A–C NIAID Category A Variola major (smallpox) and other poxviruses Viral hemorrhagic fevers Arenaviruses Lymphocytic choriomeningitis virus, Junin virus, Machupo virus, Guanarito virus Lassa virus Bunyaviruses Hantaviruses Rift Valley fever Flaviviruses Dengue Filoviruses Ebola Marburg NIAID Category B Food and waterborne pathogens (caliciviruses, hepatitis A) Viral encephalitides West Nile virus La Crosse virus California encephalitis Venezuelan, eastern, and western equine encephalitis viruses Japanese encephalitis virus Kysanur Forest virus NIAID Category C Nipah virus and additional hantaviruses Tickborne hemorrhagic fever viruses Crimean-Congo hemorrhagic fever virus Tickborne encephalitis viruses Influenza Rabies severe lower respiratory tract infections due to respiratory syncytial virus (RSV).

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